Hippocampal representation in place learning
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چکیده
منابع مشابه
Hippocampal representation in place learning.
The generality of the place-learning impairment associated with hippocampal system damage was challenged using methods of training that permitted subjects to form an individual association between the place of escape and a particular navigational route in an open-field water maze. Both normal rats and rats with fornix lesions (FX rats) acquired this task rapidly, although FX rats were slightly ...
متن کاملDiscordance of spatial representation in ensembles of hippocampal place cells.
The extent to which small ensembles of neighboring hippocampal neurons alter their spatial firing patterns concurrently in response to stimulus manipulations was examined in young adult rats as well as in aged rats with and without memory impairment. Recordings from CA1 and CA3 cells were taken as rats performed a spatial radial-maze task that employed prominent distal visual stimuli attached t...
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A computer model of learning and representing spatial locations is studied. The model builds on biological constraints and assumptions drawn from the anatomy and physiology of the hippocampal formation of the rat. The emphasis of the presented research is on the usability of a computer model originally proposed to describe episodic memory capabilities of the hippocampus in a spatial task. In th...
متن کاملReversible inactivation of the lateral dorsal thalamus disrupts hippocampal place representation and impairs spatial learning.
Place-specific discharge of hippocampal cells was monitored while rats performed daily 15 trials of a spatial memory task. During the intertrial interval between trials 5 and 6, the lateral dorsal nucleus of the thalamus (LDN) was reversibly inactivated. Choice accuracy on the maze became impaired, and many hippocampal place fields became disrupted. These data support the proposition that the L...
متن کاملContext-independent directional cue learning by hippocampal place cells.
In a symmetrical environment possessing no other polarizing visual cues, the spatially localized firing of hippocampal place cells can be primarily orientated by a reliable distal visual stimulus, such as a white cue card. However, if such a directional cue is made unreliable by being frequently moved in full view of the rat, the rat's internal sense of direction comes, over the course of a few...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1990
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.10-11-03531.1990